Transcriptomics

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Lungs of ferrets infected with either an H3N2 or H5N1 subtype of influenza A virus.


ABSTRACT: A global genomics approach was used to identify patterns of immune dysregulation during H5N1 influenza virus infection as the host response, in particular hyperchemokinemia, is thought to contribute to the extreme pathology associated with this disease. Keywords: time course Ferrets were inoculated intranasally with 10(6) EID50 of either A/Vietnam/1203/04 (H5N1) or A/Panama/2007/99 (H3N2). At 2, 4 and 6 days post-infection (DPI), ferrets were euthanized and lung tissue was excised for RNA purification and subsequent gene expression analysis.

ORGANISM(S): Mustela putorius furo  

SUBMITTER: Longsi Ran   David J Kelvin  

PROVIDER: E-GEOD-9606 | ArrayExpress | 2010-05-15

SECONDARY ACCESSION(S): GSE9606PRJNA103455

REPOSITORIES: GEO, ArrayExpress

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Publications


How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of avian influenza virus infection in humans is poorly understood. We identified three clusters of differentially expressed innate immune response genes in lungs from H5N1 (A/Vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis. Interferon response genes were more strongly expressed in H5N1-infected ferret lungs than in lungs from ferrets infected with the less pathogenic H3N  ...[more]

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