Transcriptomics

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The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97


ABSTRACT: A possible functional role of VCP/p97 during differentiation of U937 cells was addressed by siRNA-targeting of VCP/p97. Functional changes in VCP-siRNA-transfected cells following phorbol ester-induced monocytic differentiation have been examind by DNA microarray analysis. Cells transfected with the non-targeting AllStars negative siRNA (Qiagen) served as a reference. Computed

ORGANISM(S): Homo sapiens  

SUBMITTER: Doris Steinemann  

PROVIDER: E-GEOD-9821 | ArrayExpress | 2010-06-29

SECONDARY ACCESSION(S): GSE9821PRJNA103781

REPOSITORIES: GEO, ArrayExpress

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The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97.

Bertram Catharina C   von Neuhoff Nils N   Skawran Britta B   Steinemann Doris D   Schlegelberger Brigitte B   Hass Ralf R  

BMC cell biology 20080215


BACKGROUND: Retrodifferentiation and regained proliferative capacity of growth-arrested human leukemic cells after monocyte-like differentiation requires proteolytic activities together with distinct regulatory factors. The AAA ATPase valosin-containing protein (VCP/p97) contributes to protein degradation and cell cycle regulation, respectively, and it was of interest to study a possible role of VCP/p97 during this myelomonocytic differentiation and retrodifferentiation. RESULTS: Separation of a  ...[more]

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