Dataset Information


Methotrexate resistant Leishmania strains

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE9947: Transcriptional analysis of Leishmania infantum methotrexate resistant strains using full-genome DNA microarrays GSE9948: Transcriptional analysis of Leishmania major methotrexate resistant strains using full-genome DNA microarrays Keywords: SuperSeries Refer to individual Series

SUBMITTER: Marc Ouellette  

PROVIDER: E-GEOD-9949 | ArrayExpress | 2010-05-25



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Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

Ubeda Jean-Michel JM   Légaré Danielle D   Raymond Frédéric F   Ouameur Amin Ahmed AA   Boisvert Sébastien S   Rigault Philippe P   Corbeil Jacques J   Tremblay Michel J MJ   Olivier Martin M   Papadopoulou Barbara B   Ouellette Marc M  

Genome biology 20080718 7

BACKGROUND: Drug resistance can be complex, and several mutations responsible for it can co-exist in a resistant cell. Transcriptional profiling is ideally suited for studying complex resistance genotypes and has the potential to lead to novel discoveries. We generated full genome 70-mer oligonucleotide microarrays for all protein coding genes of the human protozoan parasites Leishmania major and Leishmania infantum. These arrays were used to monitor gene expression in methotrexate resistant par  ...[more]

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