Transcriptomics

Dataset Information

4

Transcription profiling of Strongyloides ratti to host immunity


ABSTRACT: Strongyloides ratti is a parasitic nematode of rats and a laboratory model for nematode infection more generally. The response of two lines of S. ratti were compared in contrasting immunological environments: (i) day 5 post infection (p.i.) in naive rats; (ii) day 12 p.i. in naive rats; day 5 p.i. in rats previously immunised with 10 iL3s; and day 12 p.i. in rats previously immunised with 10 iL3s. The gene expression response of parasitic females were assayed using cDNA microarrays. Large numbers of responding genes were found (but with modest fold changes) and clusters of co-expressed genes identified with differences observed between worms taken from naive and previously exposed hosts and from the two time points.

INSTRUMENT(S): (Make:,Model:4000B)

ORGANISM(S): Strongyloides ratti  

SUBMITTER: Helen Evans   unknown unknown 

PROVIDER: E-MAXD-53 | ArrayExpress | 2009-09-03

REPOSITORIES: ArrayExpress

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