Transcriptomics

Dataset Information

4

Transcription profiling of human breast cancer samples vs. a universal reference to define a gene expression profile associated to response to antiestrogen treatment in ERalpha-positive breast cancer from elderly patients


ABSTRACT: This study aimed to define a gene expression profile associated to response to antiestrogen treatment in ERalpha-positive breast cancer from elderly patients and to identify possible candidate genes associated to resistance by detecting those modulated by treatment.

INSTRUMENT(S): GenePix 4000B [Axon Instruments]

ORGANISM(S): Homo sapiens  

DISEASE(S): Breast Cancer

SUBMITTER: James J Reid  

PROVIDER: E-MEXP-1114 | ArrayExpress | 2008-05-07

REPOSITORIES: ArrayExpress

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Publications

Patterns and changes in gene expression following neo-adjuvant anti-estrogen treatment in estrogen receptor-positive breast cancer.

Cappelletti Vera V   Gariboldi Manuela M   De Cecco Loris L   Toffanin Sara S   Reid James F JF   Lusa Lara L   Bajetta Emilio E   Celio Luigi L   Greco Marco M   Fabbri Alessandra A   Pierotti Marco A MA   Daidone Maria Grazia MG  

Endocrine-related cancer 20080601 2


This study aimed to define a gene expression profile associated with response to anti-estrogen treatment in estrogen receptor alpha (ERalpha)-positive breast cancer from elderly patients and to identify possible candidate genes associated with resistance by detecting those modulated by treatment. Using cDNA microarrays containing 16 702 unique clones, 21 pre-treatment and 11 paired post-treatment samples collected in a neo-adjuvant toremifene trial on elderly patients with operable and locally a  ...[more]

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