Transcriptomics

Dataset Information

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Transcription profiling of three strains of fisson yeast treated with hydroxyurea for different lengths of time


ABSTRACT: Genome-wide analyses reveal checkpoint independence of most DNA replication origins during replication stress and re-replication in S. pombe

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Adam P Rosebrock  

PROVIDER: E-MEXP-1127 | ArrayExpress | 2007-11-16

REPOSITORIES: ArrayExpress

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Publications

Checkpoint independence of most DNA replication origins in fission yeast.

Mickle Katie L KL   Ramanathan Sunita S   Rosebrock Adam A   Oliva Anna A   Chaudari Amna A   Yompakdee Chulee C   Scott Donna D   Leatherwood Janet J   Huberman Joel A JA  

BMC molecular biology 20071219


In budding yeast, the replication checkpoint slows progress through S phase by inhibiting replication origin firing. In mammals, the replication checkpoint inhibits both origin firing and replication fork movement. To find out which strategy is employed in the fission yeast, Schizosaccharomyces pombe, we used microarrays to investigate the use of origins by wild-type and checkpoint-mutant strains in the presence of hydroxyurea (HU), which limits the pool of deoxyribonucleoside triphosphates (dNT  ...[more]

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