Transcriptomics,Multiomics

Dataset Information

6

Transcription profiling by array of human HepG2 cells expressing gain-of-function mutant D374Y-PCSK9


ABSTRACT: We have transfected Hep2G cells with the gain-of-function mutant D374Y-PCSK9.

INSTRUMENT(S): 418 [Affymetrix]

SUBMITTER: Morten Mattingsdal  

PROVIDER: E-MEXP-1235 | ArrayExpress | 2008-01-30

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MEXP-1235.README.txt Txt
E-MEXP-1235.eSet.r Other
E-MEXP-1235.idf.txt Idf
E-MEXP-1235.processed.1.zip Processed
E-MEXP-1235.raw.1.zip Raw
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Publications

Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9.

Ranheim Trine T   Mattingsdal Morten M   Lindvall Jessica M JM   Holla Oystein L OL   Berge Knut Erik KE   Kulseth Mari Ann MA   Leren Trond P TP  

Journal of cellular physiology 20081101 2


Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of serum cholesterol. The possibility that PCSK9 also functions in other pathways needs to be addressed. We have transfected HepG2 cells with mutant D374Y-PCSK9 or control vector. Gene expression signatures were determined using the Affymetrix GeneChip technology, and the expression pattern of selected genes was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR). Data was normalized and analyzed using a  ...[more]

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