Dataset Information


Transcription profiling of Burkholderia cepacia grown in cystic fibrosis sputum

ABSTRACT: Transcriptome profile of B. cenocepacia grown in cystic fibrosis sputum

INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]

ORGANISM(S): Burkholderia cepacia  

SUBMITTER: Pavel Drevinek  

PROVIDER: E-MEXP-1261 | ArrayExpress | 2008-01-01


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Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum.

Drevinek Pavel P   Holden Matthew T G MT   Ge Zhaoping Z   Jones Andrew M AM   Ketchell Ian I   Gill Ryan T RT   Mahenthiralingam Eshwar E  

BMC infectious diseases 20080919

Bacteria from the Burkholderia cepacia complex (Bcc) are the only group of cystic fibrosis (CF) respiratory pathogens that may cause death by an invasive infection known as cepacia syndrome. Their large genome (> 7000 genes) and multiple pathways encoding the same putative functions make virulence factor identification difficult in these bacteria.A novel microarray was designed to the genome of Burkholderia cenocepacia J2315 and transcriptomics used to identify genes that were differentially reg  ...[more]

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