Dataset Information


Transcription profiling by array of three human multiple myeloma cell lines treated with 5-aza-2-deoxycytidine and/or trichostatin A

ABSTRACT: To identify epigenetically silenced genes in multiple myeloma (MM) cell lines and to determine the effects of 5-aza-2-deoxycytidine and trichostatin A on gene expression. We treated 3 multiple myeloma cell lines (MM1, NCI-H929, U266) with 5-aza-2-deoxycytidine and/or trichostatin A.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Gerwin Heller  

PROVIDER: E-MEXP-1269 | ArrayExpress | 2008-02-01


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Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells.

Heller Gerwin G   Schmidt Wolfgang M WM   Ziegler Barbara B   Holzer Sonja S   Müllauer Leonhard L   Bilban Martin M   Zielinski Christoph C CC   Drach Johannes J   Zöchbauer-Müller Sabine S  

Cancer research 20080101 1

To identify epigenetically silenced cancer-related genes and to determine molecular effects of 5-aza-2'-deoxycytidine (Aza-dC) and/or trichostatin A (TSA) in multiple myeloma (MM), we analyzed global changes in gene expression profiles of three MM cell lines by microarray analysis. We identified up-regulation of several genes whose epigenetic silencing in MM is well known. However, much more importantly, we identified a large number of epigenetically inactivated cancer-related genes that are inv  ...[more]

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