Transcriptomics

Dataset Information

7

Transcription profiling by array of three human multiple myeloma cell lines treated with 5-aza-2-deoxycytidine and/or trichostatin A


ABSTRACT: To identify epigenetically silenced genes in multiple myeloma (MM) cell lines and to determine the effects of 5-aza-2-deoxycytidine and trichostatin A on gene expression. We treated 3 multiple myeloma cell lines (MM1, NCI-H929, U266) with 5-aza-2-deoxycytidine and/or trichostatin A.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Gerwin Heller  

PROVIDER: E-MEXP-1269 | ArrayExpress | 2008-02-01

REPOSITORIES: ArrayExpress

altmetric image

Publications

Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells.

Heller Gerwin G   Schmidt Wolfgang M WM   Ziegler Barbara B   Holzer Sonja S   Müllauer Leonhard L   Bilban Martin M   Zielinski Christoph C CC   Drach Johannes J   Zöchbauer-Müller Sabine S  

Cancer research 20080101 1


To identify epigenetically silenced cancer-related genes and to determine molecular effects of 5-aza-2'-deoxycytidine (Aza-dC) and/or trichostatin A (TSA) in multiple myeloma (MM), we analyzed global changes in gene expression profiles of three MM cell lines by microarray analysis. We identified up-regulation of several genes whose epigenetic silencing in MM is well known. However, much more importantly, we identified a large number of epigenetically inactivated cancer-related genes that are inv  ...[more]

Similar Datasets

2008-04-01 | E-MIMR-222 | ArrayExpress
2008-07-23 | E-MIMR-1241 | ArrayExpress
2007-09-01 | E-MIMR-461 | ArrayExpress
2008-06-01 | E-MIMR-341 | ArrayExpress
2008-01-08 | E-MIMR-802 | ArrayExpress
2009-10-17 | E-MEXP-2395 | ArrayExpress
2010-01-29 | E-MEXP-2313 | ArrayExpress
2008-09-12 | E-MEXP-1611 | ArrayExpress
2009-02-17 | E-TABM-38 | ArrayExpress
2008-12-31 | E-MTAB-16 | ArrayExpress