Transcriptomics

Dataset Information

8

Transcription profiling of human monocytes and monocyte-derived macrophages infected with Coxiella burnetii and incubated with apoptotic or necrotic lymphocytes


ABSTRACT: Q fever is due to Coxiella burnetii, an obligate intracellular bacterium. We investigated the mechanism of establishment of chronic form of the Q fever that mainlym anifested by endocarditis. We showed that patients with acute Q fever and valvulopathy, who have the higher risk to develop an endocarditis, exhibited high levels of circulating apoptotic cells. We further investigated the effect of the uptake of dead cells on the intracellular fate of the bacterium and the immune response of monocytes and macrophages.

INSTRUMENT(S): other

ORGANISM(S): Homo sapiens  

DISEASE(S): C. Burnetii Infected,Normal

SUBMITTER: Marie E Benoit  

PROVIDER: E-MEXP-1289 | ArrayExpress | 2008-10-09

REPOSITORIES: ArrayExpress

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Publications

The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis.

Benoit Marie M   Ghigo Eric E   Capo Christian C   Raoult Didier D   Mege Jean-Louis JL  

PLoS pathogens 20080516 5


Patients with valvulopathy have the highest risk to develop infective endocarditis (IE), although the relationship between valvulopathy and IE is not clearly understood. Q fever endocarditis, an IE due to Coxiella burnetii, is accompanied by immune impairment. Patients with valvulopathy exhibited increased levels of circulating apoptotic leukocytes, as determined by the measurement of active caspases and nucleosome determination. The binding of apoptotic cells to monocytes and macrophages, the h  ...[more]

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