Dataset Information


Transcription profiling by array of brain from zebrafish treated with ethanol or nicotine suggests conservation of neuro-adaptation pathways

ABSTRACT: Effect of ethanol or nicotine exposure on gene expression compared to control. Duplicate arrays from ethanol or nicotine treated animals compared with triplicate arrays from paired control animals. In total 4 treatment arrays (2 ethanol, 2 nicotine) and 3 control arrays (from control animals treated in parallel with ethanol-treated fish and nicotine-treated fish.)

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Danio rerio  

SUBMITTER: Caroline H Brennan  

PROVIDER: E-MEXP-1301 | ArrayExpress | 2008-05-01


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Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.

Kily Layla J M LJ   Cowe Yuka C M YC   Hussain Osman O   Patel Salma S   McElwaine Suzanne S   Cotter Finbarr E FE   Brennan Caroline H CH  

The Journal of experimental biology 20080501 Pt 10

Addiction is a complex psychiatric disorder considered to be a disease of the brain's natural reward reinforcement system. Repeated stimulation of the 'reward' pathway leads to adaptive changes in gene expression and synaptic organization that reinforce drug taking and underlie long-term changes in behaviour. The primitive nature of reward reinforcement pathways and the near universal ability of abused drugs to target the same system allow drug-associated reward and reinforcement to be studied i  ...[more]

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