Transcriptomics

Dataset Information

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Transcription profiling time series of mouse melanocytes transfected with an inducible version of the oncogenic receptor Xmrk, starved for 72 h and afterwards stimulated with EGF


ABSTRACT: Signaling pathways specifically induced by the oncogenic receptor Xmrk can be elucidated by comparing gene expression in cells with the activated receptor to gene expression in cells with the non-activated receptor. Mouse melanocytes transfected with an inducible version of the oncogenic receptor Xmrk, were starved for 72 h and afterwards stimulated with EGF. We compared cells stimulated for 15 minutes, 1 h, 2 h, 4 h, 8 h or 24 h, respectively, to unstimulated cells.

INSTRUMENT(S): ScanArray Express HT [PerkinElmer]

ORGANISM(S): Mus musculus  

SUBMITTER: Michael Krause  

PROVIDER: E-MEXP-1311 | ArrayExpress | 2008-08-31

REPOSITORIES: ArrayExpress

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Publications

Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins.

Teutschbein Janka J   Haydn Johannes M JM   Samans Birgit B   Krause Michael M   Eilers Martin M   Schartl Manfred M   Meierjohann Svenja S  

BMC cancer 20100721


BACKGROUND: Melanoma is an aggressive tumor with increasing incidence. To develop accurate prognostic markers and targeted therapies, changes leading to malignant transformation of melanocytes need to be understood. In the Xiphophorus melanoma model system, a mutated version of the EGF receptor Xmrk (Xiphophorus melanoma receptor kinase) triggers melanomagenesis. Cellular events downstream of Xmrk, such as the activation of Akt, Ras, B-Raf or Stat5, were also shown to play a role in human melano  ...[more]

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