Transcriptomics

Dataset Information

2

Transcription profiling of human ovarian cancer cell lines grown as multicellular spheroids and treated with three chemotherapy drugs


ABSTRACT: Gene expression profiling of ovarian cancer spheroids upon treatment with three chemotherapy drugs

INSTRUMENT(S): Agilent microarray scanner

ORGANISM(S): Homo sapiens  

DISEASE(S): Ovarian Cancer

SUBMITTER: Dimcho Bachvarov  

PROVIDER: E-MEXP-1319 | ArrayExpress | 2008-05-06

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MEXP-1319.README.txt Txt
E-MEXP-1319.idf.txt Idf
E-MEXP-1319.idf.txt_original Idf
E-MEXP-1319.raw.1.zip Raw
E-MEXP-1319.sdrf.txt Txt
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Publications

Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids.

L'Espérance Sylvain S   Bachvarova Magdalena M   Tetu Bernard B   Mes-Masson Anne-Marie AM   Bachvarov Dimcho D  

BMC genomics 20080226


<h4>Background</h4>Chemotherapy (CT) resistance in ovarian cancer (OC) is broad and encompasses diverse unrelated drugs, suggesting more than one mechanism of resistance. To better understand the molecular mechanisms controlling the immediate response of OC cells to CT exposure, we have performed gene expression profiling in spheroid cultures derived from six OC cell lines (OVCAR3, SKOV3, TOV-112, TOV-21, OV-90 and TOV-155), following treatment with 10,0 microM cisplatin, 2,5 microM paclitaxel o  ...[more]

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