Transcriptomics

Dataset Information

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Transcription profiling of human intestinal mucosa after exposure to Lactobacillus plantarum WCFS1


ABSTRACT: the human in vivo transcriptional response of small intestinal mucosa to Lactobacillus plantarum

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Freddy J Troost  

PROVIDER: E-MEXP-1328 | ArrayExpress | 2008-10-17

REPOSITORIES: ArrayExpress

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Publications

Identification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo.

Troost Freddy J FJ   van Baarlen Peter P   Lindsey Patrick P   Kodde Andrea A   de Vos Willem M WM   Kleerebezem Michiel M   Brummer Robert-Jan M RJ  

BMC Genomics 20080805


BACKGROUND: There is limited knowledge on the extent and dynamics of the mucosal response to commensal and probiotic species in the human intestinal lumen. This study aimed to identify the acute, time-dependent responses of intestinal mucosa to commensal Lactobacillus plantarum WCFS1 in vivo in two placebo-controlled human intervention studies in healthy volunteers. Transcriptional changes in duodenal mucosa upon continuous intraduodenal infusion of L. plantarum WCFS1 for one- and six h, respect  ...[more]

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