Transcriptomics

Dataset Information

6

Transcription profiling of Salmonella enterica Typhimurium during infection of human epithelial cells


ABSTRACT: Epithelial cells are the first cell type Salmonella Typhimurium will encounter when infecting a host. Using DNA array techology we identified the Salmonella enterica Typhimurium genes regulated inside human epithelial cells and their variation through time.

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium  

SUBMITTER: Isabelle Hautefort  

PROVIDER: E-MEXP-1368 | ArrayExpress | 2009-04-08

REPOSITORIES: ArrayExpress

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Publications

Nutritional and metabolic requirements for the infection of HeLa cells by Salmonella enterica serovar Typhimurium.

Bowden Steven D SD   Hopper-Chidlaw Amanda C AC   Rice Christopher J CJ   Ramachandran Vinoy K VK   Kelly David J DJ   Thompson Arthur A  

PloS one 20140505 5


Salmonella is the causative agent of a spectrum of human and animal diseases ranging from gastroenteritis to typhoid fever. It is a food--and water--borne pathogen and infects via ingestion followed by invasion of intestinal epithelial cells and phagocytic cells. In this study we employed a mutational approach to define the nutrients and metabolic pathways required by Salmonella enterica serovar Typhimurium during infection of a human epithelial cell line (HeLa). We deleted the key glycolytic ge  ...[more]

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