Transcriptomics

Dataset Information

8

Transcription profiling of mouse mammary epithelial cells NMuMG treatd with TGF-b1 - time series experiment


ABSTRACT: Response of mouse mammary epithelial cells NMuMG to TGF-b1 - time course experiment. Identification of novel gene targets involved in TGF-b1-driven regulation of epithelial-mesenchymal transition (EMT).

INSTRUMENT(S): microcentrifuge

ORGANISM(S): Mus musculus  

SUBMITTER: Marcin Kowanetz   Aristidis Moustakas  Ulrich Valcourt  Carl-Henrik Heldin 

PROVIDER: E-MEXP-139 | ArrayExpress | 2004-10-01

REPOSITORIES: ArrayExpress

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Publications

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.

Valcourt Ulrich U   Kowanetz Marcin M   Niimi Hideki H   Heldin Carl-Henrik CH   Moustakas Aristidis A  

Molecular biology of the cell 20050202 4


Epithelial-mesenchymal transition (EMT) contributes to normal tissue patterning and carcinoma invasiveness. We show that transforming growth factor (TGF)-beta/activin members, but not bone morphogenetic protein (BMP) members, can induce EMT in normal human and mouse epithelial cells. EMT correlates with the ability of these ligands to induce growth arrest. Ectopic expression of all type I receptors of the TGF-beta superfamily establishes that TGF-beta but not BMP pathways can elicit EMT. Ectopic  ...[more]

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