Dataset Information


Transcription profiling of human mesenchymal stem cells from two different ages of individuals and grown at different oxygen levels

ABSTRACT: Mesenchymal stem cells (MSC) are found in many adult tissues. It is generally accepted that this type of stem cell forms different types of progenitor cells, osteocytes, chondrocytes, and adipocytes. There have been also reports about these cells differentiating into cardiac myocytes and neurons. We found primary MSC enriched at the surface of spongious bone. Therefore cellular and environmentally-induced aging of MSC and their response to oxygen tension have been determined. Low oxygen levels appeared to be instructive on the stemness of MSC allowing proliferation upon stimulation while being protective with respect to differentiation and moreover low oxygen provided a milieu for extended cellular life span. Our data are furthermore indicative for cellular senescence eventually taking place in aged MSC, which however appears to complete more rapidly under mild oxidative stress.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Normal

SUBMITTER: Guenter Lepperdinger  

PROVIDER: E-MEXP-1506 | ArrayExpress | 2009-03-01


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BACKGROUND: Age-related gene expression patterns of Homo sapiens as well as of model organisms such as Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster are a basis for understanding the genetic mechanisms of ageing. For an effective analysis and interpretation of expression profiles it is necessary to store and manage huge amounts of data in an organized way, so that these data can be accessed and processed easily. DESCRIPTION: GiSAO.db (Genes involved i  ...[more]

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