Transcriptomics

Dataset Information

4

MicroRNA profiling of two stage specific rat oligodendrocytes


ABSTRACT: microRNA expression profiles in two stage-specific populations of oligodendrocytes: OPCs expressing the A2B5 ganglioside (A2B5+ cells) and OLs that are positive for the galactocerebroside marker (GalC+ cells). Cells were isolated postnatal day 7.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Pierre Lau  

PROVIDER: E-MEXP-1589 | ArrayExpress | 2008-11-11

REPOSITORIES: ArrayExpress

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Publications

Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes.

Lau Pierre P   Verrier Jonathan D JD   Nielsen Joseph A JA   Johnson Kory R KR   Notterpek Lucia L   Hudson Lynn D LD  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20081101 45


MicroRNAs (miRNAs) play important roles in modulating gene expression at the posttranscriptional level. In postnatal oligodendrocyte lineage cells, the miRNA expression profile ("microRNAome") contains 43 miRNAs whose expression dynamically changes during the transition from A2B5(+) oligodendrocyte progenitor cells to premyelinating GalC(+) cells. The combination of microRNAome profiling with analyses of the oligodendrocyte transcriptome reveals a target bias for a class of miRNAs which includes  ...[more]

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