Transcriptomics

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Transcription profiling of mouse prostate cancer TRAMP-C2 treated with demethylating agent 5-aza-2-deoxycytidine vs untreated to identify silenced transcripts


ABSTRACT: Gene expression profiling of TRAMP-C2, transgenic adenocarcinoma of mouse prostate, cell line was done after treating the cells with DNA demethylating agent 5-aza-2'-deoxycytidine (5azadC; Sigma-Aldrich, St. Louis, MO) and histone deacetylase inhibitor trichostatin A (TSA; Sigma-Aldrich), both separately and in combination. These treatments relieve epigenetic modifications, and thus reveal potentially epigenetically silenced genes amongst the genes with increased expression after the treatments.

ORGANISM(S): Mus musculus  

DISEASE(S): Prostate Cancer

SUBMITTER: Hanna E Rauhala  

PROVIDER: E-MEXP-1611 | ArrayExpress | 2008-09-12

REPOSITORIES: ArrayExpress

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