Transcriptomics

Dataset Information

3

Transcription profiling of mouseB-cell lymphomas with defined genetic alterations in p53 or p73


ABSTRACT: Induction of apoptosis by the tumor suppressor p53 is known to protect from Myc-driven lymphomagenesis. The p53 family member p73 is also a pro-apoptotic protein, which is activated in response to oncogenes like Myc. We therefore investigated whether p73 provides a similar protection from Myc-driven lymphomas as p53. To generate B-cell lymphomas with defined genetic alterations in p53 or p73, we crossed the Eµ-Myc transgenic to mice heterozygous for germ-line deletions in p53 (p53+/) or p73 (p73+/-). Lymphomas which have spontaneously developed in Eµ-Myc transgenic animals with the genotypes p53+/+, p53+/-, p73+/+, p73+/- or p73-/- were isolated when the animals were moribund and further processed for gene expression profiling with 22.5K cDNA microarrays.

ORGANISM(S): Mus musculus  

DISEASE(S): Lymphoma

SUBMITTER: Birgit Samans  

PROVIDER: E-MEXP-1620 | ArrayExpress | 2008-12-05

REPOSITORIES: ArrayExpress

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Publications

p53 and p73 in suppression of Myc-driven lymphomagenesis.

Griesmann Heidi H   Schlereth Katharina K   Krause Michael M   Samans Birgit B   Stiewe Thorsten T  

International journal of cancer 20090101 2


Induction of apoptosis by the tumor suppressor p53 is known to protect from Myc-driven lymphomagenesis. The p53 family member p73 is also a proapoptotic protein, which is activated in response to oncogenes like Myc. Here, we have investigated whether p73 provides a similar protection from Myc-driven lymphomas as p53. Confirming previous studies, the inactivation of a single p53 allele (p53+/-) strongly reduced the median survival of Emu-Myc transgenic mice from 103 to 39 days and was invariably  ...[more]

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