Dataset Information


Transcription profiling time series of Candida albicans treated with different doses of acetic acid

ABSTRACT: Wild type Candida albicans (CAI8 containing CIp10) cultures were grown in triplicate at 1 x 107 cells ml-1 in 50 ml SC-pH3.0 broth. Cultures were then treated with 0, 20, 120 or 300
mM acetic acid. Cells were harvested after zero, 10, 30, 60, 120, 210 and 300 min treatment. RNA isolated from triplicate biological replicates were compared with a standard pooled control (untreated cells).

ORGANISM(S): Candida albicans  

SUBMITTER: Mark Ramsdale  

PROVIDER: E-MEXP-1645 | ArrayExpress | 2008-07-31


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MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.

Ramsdale Mark M   Selway Laura L   Stead David D   Walker Jan J   Yin Zhikang Z   Nicholls Susan M SM   Crowe Jonathan J   Sheils Emma M EM   Brown Alistair J P AJ  

Molecular biology of the cell 20080723 10

MNL1, the Candida albicans homologue of an orphan Msn2-like gene (YER130c in Saccharomyces cerevisiae) has no known function. Here we report that MNL1 regulates weak acid stress responses. Deletion of MNL1 prevents the long-term adaptation of C. albicans cells to weak acid stresses and compromises their global transcriptional response under these conditions. The promoters of Mnl1-dependent genes contain a novel STRE-like element (SLE) that imposes Mnl1-dependent, weak acid stress-induced transcr  ...[more]

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