Transcriptomics

Dataset Information

7

Transcription profiling of human HCT116 parental cells treated with 5-FU or SN38 and non-treated parental cells, 5-FU resistant and SN39 resistant cells


ABSTRACT: The transcriptional profiles of the HCT116 parental cells following treatment with either 5-FU or SN38 for 24h were assessed. In addition, basal comparisons between HCT116 parental and HCT116 5-FU -resistant and HCT116 SN38-resistant cells were also assessed.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Colorectal Carcinoma

SUBMITTER: wendy l allen  

PROVIDER: E-MEXP-1691 | ArrayExpress | 2009-03-30

REPOSITORIES: ArrayExpress

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Publications

The colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information.

Allen Wendy L WL   Jithesh Puthen V PV   Oliver Gavin R GR   Proutski Irina I   Longley Daniel B DB   Lenz Heinz-Josef HJ   Proutski Vitali V   Harkin Paul P   Johnston Patrick G PG  

BMC cancer 20101220


To date, there are no clinically reliable predictive markers of response to the current treatment regimens for advanced colorectal cancer. The aim of the current study was to compare and assess the power of transcriptional profiling using a generic microarray and a disease-specific transcriptome-based microarray. We also examined the biological and clinical relevance of the disease-specific transcriptome.DNA microarray profiling was carried out on isogenic sensitive and 5-FU-resistant HCT116 col  ...[more]

Publication: 1/4

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