Dataset Information


MicroRNA profiling of mouse wild type and SHP knock-out liver

ABSTRACT: The microRNA expression profiles between wild type 2-month old mouse liver and small heterodimer partner (SHP) knockout mouse liver was compared using microRNA array.

ORGANISM(S): Mus musculus  

SUBMITTER: Guisheng Song  

PROVIDER: E-MEXP-1721 | ArrayExpress | 2008-09-13


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Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism.

Song Guisheng G   Wang Li L  

PloS one 20090901 9

MicroRNAs play a critical role in many essential cellular functions in the mammalian species. However, limited information is available regarding the regulation of miRNAs gene transcription. Microarray profiling and real-time PCR analysis revealed a marked down-regulation of miR-206 in nuclear receptor SHP(-/-) mice. To understand the regulatory function of SHP with regard to miR-206 gene expression, we determined the putative transcriptional initiation site of miR-206 and also its full length p  ...[more]

Publication: 1/2

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