Transcriptomics

Dataset Information

4

MicroRNA profiling of rat CG-4 oligodendrocyte progenitor cells and differentiated cells


ABSTRACT: Comparison of microRNA expression profile of CG-4 oligodendrocyte progenitor cells and differentiated cells.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Pierre Lau  

PROVIDER: E-MEXP-1764 | ArrayExpress | 2009-02-01

REPOSITORIES: ArrayExpress

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Publications

Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.

Lehotzky Attila A   Lau Pierre P   Tokési Natália N   Muja Naser N   Hudson Lynn D LD   Ovádi Judit J  

Glia 20100101 2


TPPP/p25, a recently identified tubulin polymerization-promoting protein (TPPP), is expressed mainly in myelinating oligodendrocytes of the CNS. Here, we show that TPPP/p25 is strongly upregulated during the differentiation of primary oligodendrocyte cells as well as the CG-4 cell line. The microRNA expression profile of CG-4 cells before and after induction of differentiation was established and revealed differential regulation of a limited subset of microRNAs. miR-206, a microRNA predicted to  ...[more]

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