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MicroRNA profiling of rat CG-4 oligodendrocyte progenitor cells and differentiated cells

ABSTRACT: Comparison of microRNA expression profile of CG-4 oligodendrocyte progenitor cells and differentiated cells.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Pierre Lau

PROVIDER: E-MEXP-1764 | ArrayExpress | 2009-02-01

REPOSITORIES: ArrayExpress

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Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.

Lehotzky Attila A Lau Pierre P Tokési Natália N Muja Naser N Hudson Lynn D LD Ovádi Judit J

Glia 20100101 2

TPPP/p25, a recently identified tubulin polymerization-promoting protein (TPPP), is expressed mainly in myelinating oligodendrocytes of the CNS. Here, we show that TPPP/p25 is strongly upregulated during the differentiation of primary oligodendrocyte cells as well as the CG-4 cell line. The microRNA expression profile of CG-4 cells before and after induction of differentiation was established and revealed differential regulation of a limited subset of microRNAs. miR-206, a microRNA predicted to ...[more]

PMID: 19606501

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