Dataset Information


Transcription profiling of budding yeast during meiosis to examine the effects of Cdc7p inactivation

ABSTRACT: Global effects of Cdc7p inactivation during early budding yeast meiosis

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Adam P Rosebrock  

PROVIDER: E-MEXP-1765 | ArrayExpress | 2008-10-02


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Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis.

Lo Hsiao-Chi HC   Wan Lihong L   Rosebrock Adam A   Futcher Bruce B   Hollingsworth Nancy M NM  

Molecular biology of the cell 20080903 11

In budding yeast, as in other eukaryotes, the Cdc7 protein kinase is important for initiation of DNA synthesis in vegetative cells. In addition, Cdc7 has crucial meiotic functions: it facilitates premeiotic DNA replication, and it is essential for the initiation of recombination. This work uses a chemical genetic approach to demonstrate that Cdc7 kinase has additional roles in meiosis. First, Cdc7 allows expression of NDT80, a meiosis-specific transcriptional activator required for the induction  ...[more]

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