Dataset Information


Transcription profiling of yeast strains in which Hsk1-Dfp1 has been tethered near a replication origin

ABSTRACT: Transcription profiling of strains in which Hsk1-Dfp1 has been tethered near a replication origin.

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Adam P Rosebrock  

PROVIDER: E-MEXP-1811 | ArrayExpress | 2008-09-25


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The Hsk1(Cdc7) replication kinase regulates origin efficiency.

Patel Prasanta K PK   Kommajosyula Naveen N   Rosebrock Adam A   Bensimon Aaron A   Leatherwood Janet J   Bechhoefer John J   Rhind Nicholas N  

Molecular biology of the cell 20080917 12

Origins of DNA replication are generally inefficient, with most firing in fewer than half of cell cycles. However, neither the mechanism nor the importance of the regulation of origin efficiency is clear. In fission yeast, origin firing is stochastic, leading us to hypothesize that origin inefficiency and stochasticity are the result of a diffusible, rate-limiting activator. We show that the Hsk1-Dfp1 replication kinase (the fission yeast Cdc7-Dbf4 homologue) plays such a role. Increasing or dec  ...[more]

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