Dataset Information


Transcription profiling of skeletal muscle from leptin treated wild type and obese mice

ABSTRACT: Wild type (C57BL/6J) mice were divided in control (W), leptin-treated (E) and pair-fed (F). Obese (ob/ob) mice were divided in control (O), leptin-treated (L) and pair-fed (P). Control (W and O) and pair-fed animals (F and P) received vehicle (PBS), while E and L groups were intraperitoneally administrated with leptin for 28 days. Control (W and O) and leptin-treated (E and L) groups were provided with water and food ad libitum with, while daily food intake of pair fed (F and P) groups were matched to the amount eaten by the leptin-treated groups (E and L) the day before to discriminate the inhibitory effect of leptin on appetite.

ORGANISM(S): Mus musculus  

SUBMITTER: Javier Margareto  

PROVIDER: E-MEXP-1831 | ArrayExpress | 2009-09-26


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Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice.

Sáinz Neira N   Rodríguez Amaia A   Catalán Victoria V   Becerril Sara S   Ramírez Beatriz B   Gómez-Ambrosi Javier J   Frühbeck Gema G  

Mediators of inflammation 20100630

Obese leptin-deficient ob/ob mice exhibit a low-grade chronic inflammation together with a low muscle mass. Our aim was to analyze the changes in muscle expression levels of genes related to oxidative stress and inflammatory responses in leptin deficiency and to identify the effect of in vivo leptin administration. Ob/ob mice were divided in three groups as follows: control ob/ob, leptin-treated ob/ob (1 mg/kg/d) and leptin pair-fed ob/ob mice. Gastrocnemius weight was lower in control ob/ob tha  ...[more]

Publication: 1/3

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