Dataset Information


Transcription profiling of replication checkpoint response in fission yeast

ABSTRACT: Transcription profiling of replication checkpoint response in fission yeast.

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Adam P Rosebrock  

PROVIDER: E-MEXP-1902 | ArrayExpress | 2008-11-15


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The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.

Dutta Chaitali C   Patel Prasanta K PK   Rosebrock Adam A   Oliva Anna A   Leatherwood Janet J   Rhind Nicholas N  

Molecular and cellular biology 20080728 19

The DNA replication checkpoint transcriptionally upregulates genes that allow cells to adapt to and survive replication stress. Our results show that, in the fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G(1)/S transcriptional program by directly regulating MBF, the G(1)/S transcription factor. Instead of initiating a checkpoint-specific transcriptional program, the replication checkpoint targets MBF to maintain the normal G(1)/S transcriptional program  ...[more]

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