Transcriptomics

Dataset Information

3

MicroRNA profiling of human cholangiocytes in response to interferon-gamma


ABSTRACT: Cells of a human cholangiocyte cell line (H69) were exposed to 10 ng/ml of IFN-gamma for 8 h. Cells were collected and processed for miRNA array analysis carried out by EXIQON (Denmark).

ORGANISM(S): Homo sapiens  

SUBMITTER: Xian-Ming Chen  

PROVIDER: E-MEXP-1906 | ArrayExpress | 2009-02-10

REPOSITORIES: ArrayExpress

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Publications

MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.

Gong Ai-Yu AY   Zhou Rui R   Hu Guoku G   Li Xiaoqing X   Splinter Patrick L PL   O'Hara Steven P SP   LaRusso Nicholas F NF   Soukup Garrett A GA   Dong Haidong H   Chen Xian-Ming XM  

Journal of immunology (Baltimore, Md. : 1950) 20090201 3


Biliary epithelial cells (cholangiocytes) respond to proinflammatory cytokines such as IFN-gamma and actively participate in the regulation of biliary inflammatory response in the liver. B7-H1 (also known as CD274 or PD-L1) is a member of the B7 costimulatory molecules and plays a critical immunoregulatory role in cell-mediated immune responses. In this study, we show that resting human cholangiocytes in culture express B7-H1 mRNA, but not B7-H1 protein. IFN-gamma induces B7-H1 protein expressio  ...[more]

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