Dataset Information


MicroRNA profiling of human cholangiocytes in response to interferon-gamma

ABSTRACT: Cells of a human cholangiocyte cell line (H69) were exposed to 10 ng/ml of IFN-gamma for 8 h. Cells were collected and processed for miRNA array analysis carried out by EXIQON (Denmark).

ORGANISM(S): Homo sapiens  

SUBMITTER: Xian-Ming Chen  

PROVIDER: E-MEXP-1906 | ArrayExpress | 2009-02-10


altmetric image


MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.

Gong Ai-Yu AY   Zhou Rui R   Hu Guoku G   Li Xiaoqing X   Splinter Patrick L PL   O'Hara Steven P SP   LaRusso Nicholas F NF   Soukup Garrett A GA   Dong Haidong H   Chen Xian-Ming XM  

Journal of immunology (Baltimore, Md. : 1950) 20090201 3

Biliary epithelial cells (cholangiocytes) respond to proinflammatory cytokines such as IFN-gamma and actively participate in the regulation of biliary inflammatory response in the liver. B7-H1 (also known as CD274 or PD-L1) is a member of the B7 costimulatory molecules and plays a critical immunoregulatory role in cell-mediated immune responses. In this study, we show that resting human cholangiocytes in culture express B7-H1 mRNA, but not B7-H1 protein. IFN-gamma induces B7-H1 protein expressio  ...[more]

Similar Datasets

2011-01-01 | E-MEXP-2049 | ArrayExpress
2010-02-11 | E-MEXP-2052 | ArrayExpress
2010-02-11 | E-MEXP-2050 | ArrayExpress
2009-11-06 | E-MEXP-2047 | ArrayExpress
2010-06-30 | E-MEXP-2749 | ArrayExpress
2007-08-16 | E-MEXP-1123 | ArrayExpress
2009-04-01 | E-MEXP-2006 | ArrayExpress
2014-09-01 | E-MEXP-3944 | ArrayExpress
2008-12-01 | E-MEXP-1860 | ArrayExpress
2013-08-09 | E-GEOD-49665 | ArrayExpress