Dataset Information


MicroRNA profiling of human neuroblastoma cells shows MYCN-regulated MicroRNAs repress estrogen receptor-alpha expression

ABSTRACT: Effect of MYCN expression on microRNA transcriptome in human neuroblastoma.

ORGANISM(S): Homo sapiens  

DISEASE(S): Neuroblastoma

SUBMITTER: Jakob Lovén  

PROVIDER: E-MEXP-2006 | ArrayExpress | 2009-04-01


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MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma.

Lovén Jakob J   Zinin Nikolay N   Wahlström Therese T   Müller Inga I   Brodin Petter P   Fredlund Erik E   Ribacke Ulf U   Pivarcsi Andor A   Påhlman Sven S   Henriksson Marie M  

Proceedings of the National Academy of Sciences of the United States of America 20100104 4

MYCN, a proto-oncogene normally expressed in the migrating neural crest, is in its amplified state a key factor in the genesis of human neuroblastoma (NB). However, the mechanisms underlying MYCN-mediated NB progression are poorly understood. Here, we present a MYCN-induced miRNA signature in human NB involving the activation and transrepression of several miRNA genes from paralogous clusters. Several family members derived from the miR-17 approximately 92 cluster, including miR-18a and miR-19a,  ...[more]

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