Dataset Information


MicroRNA profiling of human cholangiocyte H69 cells after infection with Cryptosporidium parvum

ABSTRACT: H69 cells were cultured in H69 medium with Cryptosporidium parvum oocysts(10 X 5 per well, for smaples 04, 05 and 06) or without oocysts(for samples 01, 02 and 03)for 8 hours and then collected for array analysis. Sample 07 was cells exposed to heated inactived oocysts.

ORGANISM(S): Homo sapiens  

SUBMITTER: Xian-Ming Chen  

PROVIDER: E-MEXP-2050 | ArrayExpress | 2010-02-11


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NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses.

Zhou Rui R   Hu Guoku G   Liu Jun J   Gong Ai-Yu AY   Drescher Kristen M KM   Chen Xian-Ming XM  

PLoS pathogens 20091204 12

Cryptosporidium parvum is a protozoan parasite that infects the gastrointestinal epithelium and causes diarrheal disease worldwide. Innate epithelial immune responses are key mediators of the host's defense to C. parvum. MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and are involved in regulation of both innate and adaptive immune responses. Using an in vitro model of human cryptosporidiosis, we analyzed C. parvum-induced miRNA expression in biliary epithelial cell  ...[more]

Publication: 1/2

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