Dataset Information


Transcription profiling by array of rat hear after injury followed by treatment with saline, urocortin I, urocortin II or tempol

ABSTRACT: The transcriptional effects of urocortin I, urocortin II and tempol were compared to saline treatment in a rat model of in vivo coronary artery occlusion model of ischaemia/reperfusion injury of 25 min ischaemia and 2 hr reperfusion.
The treatment groups were as follows (i) sham operation or LAD occlusion with infusion of (ii) saline, (iii) 15 ?g/kg Ucn I, (iv) 15 ?g/kg Ucn II and (v) 100 mg/kg tempo infused just prior to reperfusionl.
Following 2 hr reperfusion the left ventricle was removed, snap frozen, followed by RNA extraction.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

DISEASE(S): Ischaemia Reperfusion Injury

SUBMITTER: Sean P Barry  

PROVIDER: E-MEXP-2098 | ArrayExpress | 2009-03-25


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BACKGROUND:IL-17A and IL-17F are pro-inflammatory cytokines which induce the expression of several cytokines, chemokines and matrix metalloproteinases (MMPs) in target cells. IL-17 cytokines have recently attracted huge interest due to their pathogenic role in diseases such as arthritis and inflammatory bowel disease although a role for IL-17 cytokines in myocardial infarction (MI) has not previously been described. METHODS:In vivo MI was performed by coronary artery occlusion in the absence or  ...[more]

Publication: 1/2

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