Transcriptomics

Dataset Information

18

MiRNA profiling of mouse primary peritoneal macrophages infected with vesicular stomatitis virus (VSV)


ABSTRACT: To investigate whether and what miRNAs expression might be regulated by VSV (vesicular stomatitis virus?) challenge, we analyzed the miRNA expression profile of mouse primary peritoneal macrophages infected with VSV by using an array-based miRNA profiling. After the infection of VSV at MOI 10 for 48 h, the array revealed that many miRNAs were up-regulated in macrophages?

ORGANISM(S): Mus musculus  

DISEASE(S): Vsv Infection,Normal

SUBMITTER: Jin Hou  

PROVIDER: E-MEXP-2110 | ArrayExpress | 2009-05-11

REPOSITORIES: ArrayExpress

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Publications

MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.

Hou Jin J   Wang Pin P   Lin Li L   Liu Xingguang X   Ma Feng F   An Huazhang H   Wang Zhugang Z   Cao Xuetao X  

Journal of immunology (Baltimore, Md. : 1950) 20090713 3


Upon recognition of viral components by pattern recognition receptors, including TLRs and retinoic acid-inducible gene I (RIG-I)- like helicases, cells are activated to produce type I IFN and proinflammatory cytokines. These pathways are tightly regulated by host to prevent inappropriate cellular response, but viruses can down-regulate these pathways for their survival. Recently, identification of negative regulators for cytoplasmic RNA-mediated antiviral signaling, especially the RIG-I pathway,  ...[more]

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