Ontology highlight
ABSTRACT:
INSTRUMENT(S): 418 [Affymetrix]
DISEASE(S): Orchidectomized
SUBMITTER: Klara Sjögren
PROVIDER: E-MEXP-2192 | ArrayExpress | 2009-06-12
REPOSITORIES: ArrayExpress
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E-MEXP-2192.idf.txt | Idf | |||
E-MEXP-2192.raw.1.zip | Raw | |||
E-MEXP-2192.sdrf.txt | Txt |
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Svensson Johan J Movérare-Skrtic Sofia S Windahl Sara S Swanson Charlotte C Sjögren Klara K
Journal of molecular endocrinology 20100430 1
Testosterone is a major regulator of muscle mass. Little is known whether this is due to a direct stimulation of the androgen receptor (AR) or mediated by aromatization of testosterone to estradiol (E(2)), the ligand for the estrogen receptors (ERs), in peripheral tissues. In this study, we differentiated between the effects mediated by AR and ER by treating orchidectomized (orx) male mice for 5 weeks with E(2) or the non-aromatizable androgen dihydrotestosterone (DHT). Both E(2) and DHT increas ...[more]