Dataset Information


Transcription profiling of mouse after gonadectomy and treatment with estradiol, dihydrotestosterone or vehicle to compare gene expression in gastrocnemius

ABSTRACT: Treatment of gonadectomized mice with estradiol, dihydrotestosterone or vehicle to compare gene expression in gastrocnemius.

INSTRUMENT(S): 418 [Affymetrix]

DISEASE(S): Orchidectomized

SUBMITTER: Klara Sjögren  

PROVIDER: E-MEXP-2192 | ArrayExpress | 2009-06-12


Dataset's files

Action DRS
E-MEXP-2192.idf.txt Idf Raw
E-MEXP-2192.sdrf.txt Txt
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Stimulation of both estrogen and androgen receptors maintains skeletal muscle mass in gonadectomized male mice but mainly via different pathways.

Svensson Johan J   Movérare-Skrtic Sofia S   Windahl Sara S   Swanson Charlotte C   Sjögren Klara K  

Journal of molecular endocrinology 20100430 1

Testosterone is a major regulator of muscle mass. Little is known whether this is due to a direct stimulation of the androgen receptor (AR) or mediated by aromatization of testosterone to estradiol (E(2)), the ligand for the estrogen receptors (ERs), in peripheral tissues. In this study, we differentiated between the effects mediated by AR and ER by treating orchidectomized (orx) male mice for 5 weeks with E(2) or the non-aromatizable androgen dihydrotestosterone (DHT). Both E(2) and DHT increas  ...[more]

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