Dataset Information


Transcription profiling of Salmonella enterica serovar Typhimurium SL1344 and a ramA over-expressing strain

ABSTRACT: The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 and an isogenic ramA gene knockout mutant which contained ramA upon an IPTG-inducible over-expression plasmid.

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium  

SUBMITTER: Andrew M Bailey  

PROVIDER: E-MEXP-2195 | ArrayExpress | 2009-12-31


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RamA, a member of the AraC/XylS family, influences both virulence and efflux in Salmonella enterica serovar Typhimurium.

Bailey Andrew M AM   Ivens Al A   Kingsley Rob R   Cottell Jennifer L JL   Wain John J   Piddock Laura J V LJ  

Journal of bacteriology 20100115 6

The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 lacking a functional ramA or ramR or with plasmid-mediated high-level overexpression of ramA were compared to those of the wild-type parental strain. Inactivation of ramA led to increased expression of 14 SPI-1 genes and decreased expression of three SPI-2 genes, and it altered expression of ribosomal biosynthetic genes and several amino acid biosynthetic pathways. Furthermore, disruption of ramA led to decreased survival withi  ...[more]

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