Dataset Information


Transcription profiling of human prostate cancer cells over-expressing androgen receptor following dihydrotestosterone treament

ABSTRACT: dose and time dependent responses of dihydrotestosterone in androgen receptor over-expressing prostate cancer cells.

ORGANISM(S): Homo sapiens  

DISEASE(S): Prostate Carcinoma

SUBMITTER: Kati K Waltering  

PROVIDER: E-MEXP-2286 | ArrayExpress | 2009-10-09


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Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.

Waltering Kati K KK   Helenius Merja A MA   Sahu Biswajyoti B   Manni Visa V   Linja Marika J MJ   Jänne Olli A OA   Visakorpi Tapio T  

Cancer research 20091006 20

Androgen receptor (AR) is known to be overexpressed in castration-resistant prostate cancer. To interrogate the functional significance of the AR level, we established two LNCaP cell sublines expressing in a stable fashion two to four times (LNCaP-ARmo) and four to six times (LNCaP-ARhi) higher level of AR than the parental cell line expressing the empty vector (LNCaP-pcDNA3.1). LNCaP-ARhi cell line grew faster than the control line in low concentrations, especially in 1 nmol/L 5alpha-dihydrotes  ...[more]

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