Transcriptomics

Dataset Information

2

Transcription profiling of human prostate cancer cells over-expressing androgen receptor following dihydrotestosterone treament


ABSTRACT: dose and time dependent responses of dihydrotestosterone in androgen receptor over-expressing prostate cancer cells.

ORGANISM(S): Homo sapiens  

DISEASE(S): Prostate Carcinoma

SUBMITTER: Kati K Waltering  

PROVIDER: E-MEXP-2286 | ArrayExpress | 2009-10-09

REPOSITORIES: ArrayExpress

altmetric image

Publications

Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.

Waltering Kati K KK   Helenius Merja A MA   Sahu Biswajyoti B   Manni Visa V   Linja Marika J MJ   Jänne Olli A OA   Visakorpi Tapio T  

Cancer research 20091006 20


Androgen receptor (AR) is known to be overexpressed in castration-resistant prostate cancer. To interrogate the functional significance of the AR level, we established two LNCaP cell sublines expressing in a stable fashion two to four times (LNCaP-ARmo) and four to six times (LNCaP-ARhi) higher level of AR than the parental cell line expressing the empty vector (LNCaP-pcDNA3.1). LNCaP-ARhi cell line grew faster than the control line in low concentrations, especially in 1 nmol/L 5alpha-dihydrotes  ...[more]

Similar Datasets

2011-02-25 | E-MEXP-2602 | ArrayExpress
2009-04-02 | E-TABM-626 | ArrayExpress
2009-06-08 | E-GEOD-14043 | ArrayExpress
2014-04-11 | E-GEOD-56669 | ArrayExpress
2007-09-15 | E-GEOD-8645 | ArrayExpress
2007-09-15 | E-GEOD-8533 | ArrayExpress
2016-06-30 | E-GEOD-77763 | ArrayExpress
2014-07-03 | E-GEOD-56913 | ArrayExpress
2014-07-03 | E-GEOD-56874 | ArrayExpress
2014-07-03 | E-GEOD-56875 | ArrayExpress