Dataset Information


Transcription profiling of mouse pancreatic P03 adenocarcinoma to study the effect of meal timing.

ABSTRACT: B6D2F1 male mice at the age of 6 weeks were maintained for one week in a 12h light / 12 h dark (LD12:12) cycle (lights on from 7:00 am to 7:00 pm) and food and water ad libitum. Mice were then divided in two experimental groups which were further maintained for 3 weeks in the LD12 cycle and fed either at libitum or only during a 4 h period between 9:00 am and 1:00 pm. All animals were then implanted subcutaneously with a pancreatic P03 adenocarcinoma in both flanks. Tumour growth was monitored daily and twenty one days after innoculation, animals were transfered to constant darkness for 24h. Tumour samples were collected at the implantation site at circadian time (CT)4 and CT16.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus Musculus

SUBMITTER: Franck Delaunay  

PROVIDER: E-MEXP-2462 | ArrayExpress | 2010-05-07


Dataset's files

Action DRS
E-MEXP-2462.README.txt Txt
E-MEXP-2462.eSet.r Other
E-MEXP-2462.idf.txt Idf
E-MEXP-2462.idf.txt_original Idf Processed
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Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing.

Li Xiao-Mei XM   Delaunay Franck F   Dulong Sandrine S   Claustrat Bruno B   Zampera Sinisa S   Fujii Yoshiro Y   Teboul Michèle M   Beau Jacques J   Lévi Francis F  

Cancer research 20100401 8

Circadian disruption accelerates cancer progression, whereas circadian reinforcement could halt it. Mice with P03 pancreatic adenocarcinoma (n = 77) were synchronized and fed ad libitum (AL) or with meal timing (MT) from Zeitgeber time (ZT) 2 to ZT6 with normal or fat diet. Tumor gene expression profiling was determined with DNA microarrays at endogenous circadian time (CT) 4 and CT16. Circadian mRNA expression patterns were determined for clock genes Rev-erbalpha, Per2, and Bmal1, cellular stre  ...[more]

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