Dataset Information


Transcription profiling of human hematopoietic stem cell like fractions from individuals with the M2 subtype of acute myeloid leukemia

ABSTRACT: AC133+ cells were prepared from bone marrow of individuals with acute myeloid leukemia (AML) with M2 subtype. Comparison was made between de novo AML and MDS-associated AML.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

DISEASE(S): Acute Myeloid Leukemia,Mds-associated Acute Myeloid Leukemia

SUBMITTER: Shuichi Ueno   Masuzu Ueda  Young L Choi  Keiya Ozawa  Akio Fujimura  Yoshihiro Yamashita  Yasuo Oshima  Hiroyuki Mano  Ruri Ohki  Koji Koinuma  Jun Ota  Tomoaki Wada 

PROVIDER: E-MEXP-25 | ArrayExpress | 2003-10-09


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DNA microarray analysis of hematopoietic stem cell-like fractions from individuals with the M2 subtype of acute myeloid leukemia.

Oshima Y   Ueda M   Yamashita Y   Choi YL   Ota J   Ueno S   Ohki R   Koinuma K   Wada T   Ozawa K   Fujimura A   Mano H  

Leukemia 20031001 10

Acute myeloid leukemia (AML) may develop de novo or secondarily to myelodysplastic syndrome (MDS). Although the clinical outcome of MDS-related AML is worse than that of de novo AML, it is not easy to differentiate between these two clinical courses without a record of prior MDS. Large-scale profiling of gene expression by DNA microarray analysis is a promising approach with which to identify molecular markers specific to de novo or MDS-related AML. This approach has now been adopted with AC133-  ...[more]

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