Dataset Information


Transcription profiling of Clostridium acetobutylicum during acidogenesis and solventogenesis

ABSTRACT: Clostridium acetobutylicum is characterized by its acetone-butanol (AB) fermentation which
can be reproducibly established under continuous grow conditions in a chemostat.
At pH 5.7 cells show typical acidogenic metabolism and mainly produce the acids
acetate and butyrate. After lowering and further control the external pH at 4.5
the exponentially growing cells switch towards stable solvent production with the
dominating fermentation products acetone and butanol.
Here we present a comprehensive comparison of proteome and transcriptome
data of continuously growing cells of C. acetobutylicum in a chemostat culture
under phosphate limitation at pH 5.7 (acidogenesis) and pH 4.5 (solventogenesis).

ORGANISM(S): Clostridium acetobutylicum  

SUBMITTER: Holger Janssen  

PROVIDER: E-MEXP-2503 | ArrayExpress | 2010-11-10


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A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture.

Janssen Holger H   Döring Christina C   Ehrenreich Armin A   Voigt Birgit B   Hecker Michael M   Bahl Hubert H   Fischer Ralf-Jörg RJ  

Applied microbiology and biotechnology 20100709 6

The complex changes in the life cycle of Clostridium acetobutylicum, a promising biofuel producer, are not well understood. During exponential growth, sugars are fermented to acetate and butyrate, and in the transition phase, the metabolism switches to the production of the solvents acetone and butanol accompanied by the initiation of endospore formation. Using phosphate-limited chemostat cultures at pH 5.7, C. acetobutylicum was kept at a steady state of acidogenic metabolism, whereas at pH 4.5  ...[more]

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