Transcriptomics

Dataset Information

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Transcriptional profiling of mouse non-metastatic and metastatic melanoma cells with and without 5AzaCdR treatment.


ABSTRACT: Comparison of melanoma cell lineages responses to 5AzaCdR with control

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

DISEASE(S): Non-metastatic Melanoma,Metastatic Melanoma

SUBMITTER: Miriam G Jasiulionis  

PROVIDER: E-MEXP-2517 | ArrayExpress | 2010-12-30

REPOSITORIES: ArrayExpress

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Publications

Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.

de Souza Camila Ferreira CF   Xander Patrícia P   Monteiro Ana Carolina AC   Silva Amanda Gonçalves dos Santos AG   da Silva Débora Castanheira Pereira DC   Mai Sabine S   Bernardo Viviane V   Lopes José Daniel JD   Jasiulionis Miriam Galvonas MG  

PloS one 20120911 9


BACKGROUND: Metastatic melanoma is a highly aggressive skin cancer and currently resistant to systemic therapy. Melanomas may involve genetic, epigenetic and metabolic abnormalities. Evidence is emerging that epigenetic changes might play a significant role in tumor cell plasticity and metastatic phenotype of melanoma cells. PRINCIPAL FINDINGS: In this study, we developed a systematic approach to identify genes implicated in melanoma progression. To do this, we used the Affymetrix GeneChip Array  ...[more]

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