Transcriptomics

Dataset Information

3

Transcriptional profiling of Enterococcus faecalis cells exposed to sodium bicarbonate for 15 minutes in the ate exponential growth phase.


ABSTRACT: In an effort to begin to delineate the bicarbonate regulon, we used microarray analysis with cells grown to late exponential growth phase (3 hr) and then submitted to a 15 min exposure with 0.1 M NaHCO3. Our goal was to define the first set of genes affected by the presence of bicarbonate.

ORGANISM(S): Enterococcus faecalis  

SUBMITTER: Agathe Bourgogne  

PROVIDER: E-MEXP-2518 | ArrayExpress | 2010-01-06

REPOSITORIES: ArrayExpress

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Publications

Bicarbonate enhances expression of the endocarditis and biofilm associated pilus locus, ebpR-ebpABC, in Enterococcus faecalis.

Bourgogne Agathe A   Thomson L Charlene LC   Murray Barbara E BE  

BMC Microbiology 20100121


We previously identified ebpR, encoding a potential member of the AtxA/Mga transcriptional regulator family, and showed that it is important for transcriptional activation of the Enterococcus faecalis endocarditis and biofilm associated pilus operon, ebpABC. Although ebpR is not absolutely essential for ebpABC expression (100-fold reduction), its deletion led to phenotypes similar to those of an ebpABC mutant such as absence of pili at the cell surface and, consequently, reduced biofilm formatio  ...[more]

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