Transcriptomics,Multiomics

Dataset Information

4

Transcription profiling by array of rat cardiomyocetes after treatment with insulin


ABSTRACT: Effect of insulin on the cardiomyocyte global transcriptome and RNAs recruited to polysomes.
For comparison with endothelin-1

REANALYSED by: E-MEXP-2527

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Angela Clerk  

PROVIDER: E-MEXP-2527 | ArrayExpress | 2010-07-04

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MEXP-2527.idf.txt Idf
E-MEXP-2527.processed.1.zip Processed
E-MEXP-2527.raw.1.zip Raw
E-MEXP-2527.sdrf.txt Txt
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Publications

Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.

Markou Thomais T   Marshall Andrew K AK   Cullingford Timothy E TE   Tham El L el L   Sugden Peter H PH   Clerk Angela A  

BMC genomics 20100529


<h4>Background</h4>Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also increases the rate of translation but does not promote overt cardiomyocyte hypertrophy. One mechanism of translational regulation is through 5' terminal oligopyrimidine tracts (TOPs) that, in response to growth stimul  ...[more]

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