Dataset Information


Transcription profiling by array of rat cardiomyocetes after treatment with insulin

ABSTRACT: Effect of insulin on the cardiomyocyte global transcriptome and RNAs recruited to polysomes.
For comparison with endothelin-1


ORGANISM(S): Rattus norvegicus  

SUBMITTER: Angela Clerk  

PROVIDER: E-MEXP-2527 | ArrayExpress | 2010-07-04


Dataset's files

Action DRS
E-MEXP-2527.idf.txt Idf Processed Raw
E-MEXP-2527.sdrf.txt Txt
Items per page:
1 - 4 of 4
altmetric image


Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.

Markou Thomais T   Marshall Andrew K AK   Cullingford Timothy E TE   Tham El L el L   Sugden Peter H PH   Clerk Angela A  

BMC genomics 20100529

<h4>Background</h4>Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also increases the rate of translation but does not promote overt cardiomyocyte hypertrophy. One mechanism of translational regulation is through 5' terminal oligopyrimidine tracts (TOPs) that, in response to growth stimul  ...[more]

Similar Datasets

2011-01-01 | E-MTAB-281 | ArrayExpress
2010-01-21 | E-MEXP-2497 | ArrayExpress
2010-11-10 | E-MEXP-2453 | ArrayExpress
2008-07-31 | E-MEXP-1641 | ArrayExpress
2017-02-23 | E-MTAB-5437 | ArrayExpress
2014-04-15 | E-MTAB-916 | ArrayExpress
2012-02-06 | E-MEXP-3541 | ArrayExpress
2013-09-01 | E-GEOD-47713 | ArrayExpress
2009-02-01 | E-MEXP-1764 | ArrayExpress
2010-12-30 | E-MEXP-2512 | ArrayExpress