Dataset Information


Transcription profiling in primary mouse hepatocytes discriminates between true and false genotoxic compounds

ABSTRACT: Primary mouse hepatocytes are applied in this study as an in vitro system to discriminate false positive GTX compounds from true GTX compounds.

ORGANISM(S): Mus musculus  

SUBMITTER: Danyel Jennen  

PROVIDER: E-MEXP-2539 | ArrayExpress | 2011-01-11


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Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes.

Sutherland Jeffrey J JJ   Jolly Robert A RA   Goldstein Keith M KM   Stevens James L JL  

PLoS computational biology 20160330 3

The effect of drugs, disease and other perturbations on mRNA levels are studied using gene expression microarrays or RNA-seq, with the goal of understanding molecular effects arising from the perturbation. Previous comparisons of reproducibility across laboratories have been limited in scale and focused on a single model. The use of model systems, such as cultured primary cells or cancer cell lines, assumes that mechanistic insights derived from the models would have been observed via in vivo st  ...[more]

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