Dataset Information


Transcription profiling of human H1299 cells and Saos-2 cells (p53 null cells) transfected with Flag vector, Flag-p53 WT or Flag-p53 SA

ABSTRACT: H1299 cells and Saos-2 cells (p53 null cells) were transfected with Flag vector, Flag-p53 WT or Flag-p53 SA.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Junko Kimura  

PROVIDER: E-MEXP-2556 | ArrayExpress | 2010-10-14


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Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.

Taira Naoe N   Yamaguchi Tomoko T   Kimura Junko J   Lu Zheng-Guang ZG   Fukuda Shinji S   Higashiyama Shigeki S   Ono Masaya M   Yoshida Kiyotsugu K  

Proceedings of the National Academy of Sciences of the United States of America 20131230 2

Upon DNA damage, tumor suppressor p53 determines cell fate by repairing DNA lesions to survive or by inducing apoptosis to eliminate damaged cells. The decision is based on its posttranslational modifications. Especially, p53 phosphorylation at Ser46 exerts apoptotic cell death. However, little is known about the precise mechanism of p53 phosphorylation on the induction of apoptosis. Here, we show that amphiregulin (AREG) is identified for a direct target of Ser46 phosphorylation via the compreh  ...[more]

Publication: 1/2

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