Transcriptomics

Dataset Information

10

Transcription profiling of human myelogenous leukemia K562 cells expressing BASP1


ABSTRACT: We have analysed the dynamic between WT1 and BASP1 in the regulation of gene expression in myelogenous leukaemia K562 cells. Our analysis reveals that BASP1 is a significant regulator of WT1 that is recruited to WT1-binding sites and suppresses WT1-mediated transcriptional activation at several WT1 target genes. We found that WT1 and BASP1 can divert the differentiation program of K562 cells to a non-blood cell type following induction by the phorbol ester PMA. Cell lines were generated expressing the BASP1 gene from the vector pcDNA3. Array analysis was performed on 4 conditions: cells expressing BASP1 and controls, in the absence and presence of Phorbol 12-myristate 13-acetate (PMA).

INSTRUMENT(S): 418 [Affymetrix]

DISEASE(S): Myelogenous Leukaemia

SUBMITTER: Leo Zeef  

PROVIDER: E-MEXP-2573 | ArrayExpress | 2010-12-18

REPOSITORIES: ArrayExpress

Dataset's files

Source:
Action DRS
E-MEXP-2573.README.txt Txt
E-MEXP-2573.eSet.r Other
E-MEXP-2573.idf.txt Idf
E-MEXP-2573.idf.txt_original Idf
E-MEXP-2573.processed.1.zip Processed
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