Transcriptomics

Dataset Information

3

Transcription profiling by array of human embryonic stem cell line H9 in response to ionizing radiation.


ABSTRACT: The study aimed to elucidate the whole human genome wide changes in gene expression in cultured human embryonic stem cells after ionizing radiation exposures

ORGANISM(S): Homo sapiens  

SUBMITTER: Mykyta Sokolov  

PROVIDER: E-MEXP-2596 | ArrayExpress | 2011-05-04

REPOSITORIES: ArrayExpress

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Publications

Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure.

Sokolov Mykyta V MV   Panyutin Irina V IV   Panyutin Igor G IG   Neumann Ronald D RD  

Mutation research 20110303


One of the key consequences of exposure of human cells to genotoxic agents is the activation of DNA damage responses (DDR). While the mechanisms underpinning DDR in fully differentiated somatic human cells have been studied extensively, molecular signaling events and pathways involved in DDR in pluripotent human embryonic stem cells (hESC) remain largely unexplored. We studied changes in the human genome-wide transcriptome of H9 hESC line following exposures to 1Gy of gamma-radiation at 2h and 1  ...[more]

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