Dataset Information


Transcription profiling of human cells line with different Dq values to assay radiosensitivity

ABSTRACT: Expression analysis between cell lines that show different "Dq" which is one of the parameters for radiosensitivity. This experiment includes three experimental factors: cell line, irradiation dose and time after irradiation.

INSTRUMENT(S): (Make:Agilent Technologies,Model:G2505A DNA microarray scanner)

ORGANISM(S): Homo sapiens  

DISEASE(S): Adenocarcinoma,Colorectal Carcinoma,Glioma,Primary Ductal Carcinoma,Medulloblastoma,Amelanotic Melanoma,Glioblastoma,Squamous Cell Carcinoma,Gliosarcoma,Normal,Normal Skin Fibroblast,Astrocytoma

SUBMITTER: Atsuko Ishikawa  

PROVIDER: E-MEXP-273 | ArrayExpress | 2006-01-16


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Gene expression profile changes correlating with radioresistance in human cell lines.

Ishikawa Ken-ichi K   Koyama-Saegusa Kumiko K   Otsuka Yoshimi Y   Ishikawa Atsuko A   Kawai Seiko S   Yasuda Kaori K   Suga Tomo T   Michikawa Yuichi Y   Suzuki Masao M   Iwakawa Mayumi M   Imai Takashi T  

International journal of radiation oncology, biology, physics 20060501 1

PURPOSE: To identify gene expression profiles specific to radioresistance of human cells. METHODS AND MATERIALS: Global gene expression profiles of a total of 15 tumor and normal fibroblast cell lines were analyzed using DNA microarrays and statistical clustering methods. Initially, six of the cell lines were categorized into radioresistant (RG) or nonradioresistant (NRG) groups according to the radiation dose required to reduce their survival to 10% (D10). Genes for which expression was specifi  ...[more]

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