Ontology highlight
ABSTRACT:
ORGANISM(S): Musculus
SUBMITTER: Tomas W Fitzgerald
PROVIDER: E-MEXP-2788 | ArrayExpress | 2010-09-01
REPOSITORIES: ArrayExpress
Action | DRS | |||
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E-MEXP-2788.README.txt | Txt | |||
E-MEXP-2788.idf.txt | Idf | |||
E-MEXP-2788.idf.txt_original | Idf | |||
E-MEXP-2788.processed.1.zip | Processed | |||
E-MEXP-2788.raw.1.zip | Raw |
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Nucleic acids research 20110924 22
The development of technologies that allow the stable delivery of large genomic DNA fragments in mammalian systems is important for genetic studies as well as for applications in gene therapy. DNA transposons have emerged as flexible and efficient molecular vehicles to mediate stable cargo transfer. However, the ability to carry DNA fragments >10 kb is limited in most DNA transposons. Here, we show that the DNA transposon piggyBac can mobilize 100-kb DNA fragments in mouse embryonic stem (ES) ce ...[more]