Dataset Information


Transcription profiling by array of mouse promyelocyte granulocytes with activated MYC-ER protein

ABSTRACT: The mouse promyelocyte (MPRO) granulocyte cell model expressing the MYC-ER fusion protein encoding transgene was used as a system to perform gene expression profiling in a granulocytic cell setting of low endogenous MYC expression (differentiated MYC-ER MPROs, D4) where we then activated the MYC-ER protein for 24 h with 4-OHT (D5T) as compared to a EtOH vehicle treated control (D5E).

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Gretchen Poortinga  

PROVIDER: E-MEXP-2794 | ArrayExpress | 2011-05-04


Dataset's files

Action DRS
E-MEXP-2794.README.txt Txt
E-MEXP-2794.eSet.r Other
E-MEXP-2794.idf.txt Idf
E-MEXP-2794.idf.txt_original Idf Processed
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c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation.

Poortinga Gretchen G   Wall Meaghan M   Sanij Elaine E   Siwicki Kasia K   Ellul Jason J   Brown Daniel D   Holloway Timothy P TP   Hannan Ross D RD   McArthur Grant A GA  

Nucleic acids research 20101221 8

Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion of the MYC target gene upstream binding factor (UBF) and a switch from epigenetically active to silent rDNA accompanies this MYC reduction. We hypothesized that MYC may coordinate these mechanisms via direct regulation of multiple components of t  ...[more]

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