Dataset Information


Transcription profiling by array of Bordetella bronchiseptica strains RB50 and 761 grown in normal or high carbon dioxide conditions

ABSTRACT: Comparison of B. bronchiseptica strains RB50 and 761 grown in either atmospheric concentrations of oxygen and carbon dioxide (normal conditions) or in atmospheric levels of oxygen with the addition of 5% carbon dioxide into a sealed incubator (5% CO2 conditions).

ORGANISM(S): Bordetella bronchiseptica  

SUBMITTER: Tracy L Nicholson  

PROVIDER: E-MEXP-2875 | ArrayExpress | 2010-10-01


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Identification of a CO2 responsive regulon in Bordetella.

Hester Sara E SE   Lui Minghsun M   Nicholson Tracy T   Nowacki Daryl D   Harvill Eric T ET  

PloS one 20121024 10

Sensing the environment allows pathogenic bacteria to coordinately regulate gene expression to maximize survival within or outside of a host. Here we show that Bordetella species regulate virulence factor expression in response to carbon dioxide levels that mimic in vivo conditions within the respiratory tract. We found strains of Bordetella bronchiseptica that did not produce adenylate cyclase toxin (ACT) when grown in liquid or solid media with ambient air aeration, but produced ACT and additi  ...[more]

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